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Exposure to glutamate leads to a decrease in GSH levels and an accumulation of intracellular peroxides, resulting in oxidative stress and cell death ( As talked about previously, tumor-associated immunotherapy studies have shown that CD8 + T cells enhance ferroptosis-specific lipid peroxidation in tumor cells

In line with the relationship between ROS and cancer it has been suggested that antioxidants may protect against cancer

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Moreover, HGF cooperates with nerve growth factor (NGF) in vitro to enhance the axonal growth of dorsal root ganglion sensory neurons (Maina et al., 1997) and sympathetic neurons (Maina et al., 1998)